The pharmaceutical industry values dosage forms that are not only more appealing but also
possess a longer shelf life, thereby improving patient compliance. Medicines are available in
various dosage forms for ease of administration, consumption, convenience, accuracy, and
bioavailability. Ayurveda has mentioned different routes of drug administration for the
effective application and absorption of medicine for achieving desired therapeutic action. The
rectal route is one of them, and within it lies the unexplored potential of Guda Varti as a simple
dosage form.
Panchatikta Kashaya, a widely used clinical formulation for fever management, consists of five
bitter ingredients, hence called Tiktaka. Variations exist in its ingredients across references,
with this specific formulation sourced from Cakradatta Jwara Chikitsa [1]. The modified
Panchatikta Kashaya Varti aims to enhance absorption and bioavailability by bypassing first-
pass metabolism. It addresses challenges like oral ingestion difficulties in patients, including
paralysis or children. By transforming into a Guda Varti, it offers a solution to overcome the
bitterness of the Kashaya, aiding in alleviating various types of Jwara.
In the pharmaceutical study, 227 grams of Ghana was obtained from 20 liters of Kashaya, then
used for Varti preparation with cocoa butter as base. Panchatikta Kashaya Varti was subjectedfor organoleptic, physicochemical, and phytochemical evaluations, setting preliminary
standards. Parameters like pH 6, Disintegration time 17.42 minutes, Loss on drying 18.2%,
Alcohol soluble extractive 24%, and Hardness 4kg were observed. Phytochemical analysis
showed presence of carbohydrates, proteins, glycosides, saponins, flavonoids, and tannins, all
with known antipyretic effects. Upon qualitative analysis of Panchatikta Kashaya Varti show
the potential therapeutic value, suggesting its promising role as an antipyretic agent.
Keywords: Panchatikta Kashaya, Modification, Varti, Antipyretic effect
Publication date: 01/08/2025
https://ijbpas.com/pdf/2025/August/MS_IJBPAS_2025_9345.pdf
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https://doi.org/10.31032/IJBPAS/2025/14.8.9345
