ABSTRACT

The exploration of heterocycles as privileged structures in drug discovery is, beyond doubt, one of the major areas in medicinal chemistry. These privileged structures represent a class of molecules that act as ligands for various biological receptors with a high degree of binding affinity. Problems of multi-drug resistant microorganisms have reached on alarming level in many countries around the world. A series of urea and thiourea derivatives of s-triazine have been developed based on high yielding nucleophilic substitution of 2,4,6-trichloro-1,3,5-triazine by 4-hydroxy coumarin, cyclopropylamine and ammonia at suitable conditions. Most of the synthesized compounds possesses potent antibacterial activities against various Gram-positive and Gram-negative strains of bacteria. A few compounds showed good to superior in vitro antibacterial activity against S.aureus, B.subtilis, E.coli and P. aeruginosa. Infections caused by those microorganisms pose a serious challenge to the medical community and the need for an effective therapy has led to a search for novel antimicrobial agents. Exploitation of these molecules should allow us to rapidly discover new biologically active compounds across a broad range of therapeutic areas in a shorter time scale. In this review article, we have discussed the novel synthesis and antibacterial activity of s-triazinyl urea and thiourea analogues, a class of privileged structures that have a wide range of biological properties. Keywords: Heterocycles, triazine, thiourea, coumarin, antibacterial
Publication date: 01/08/2025

https://ijbpas.com/pdf/2025/August/MS_IJBPAS_2025_9270.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.8.9270