ABSTRACT

Introduction: Osteoarthritis (OA) is one of the most common forms of arthritis. Diacerin, is used in the treatment of osteoarthritis. It is classified as BCS class II drug with low solubility and high permeability. In this work, Diacerin loaded solid lipid nanoparticles (SLNs) were developed to improve the oral bioavailability. Methods: The Diacerin loaded nanoparticles were prepared by hot homogenization followed by ultrasonication method using varying concentrations of lipids such as Trimyristin, Tripalmitin and Tristearin. Total six formulations were developed (F1-F6). Further, various physicochemical properties, morphology of SLNs were characterized. The physical stability study was conducted on optimized formulation at room temperature and refrigerated conditions for 3 months. Results: Among all the formulations, the F3 formulation prepared with Tripalmitin was selected as the best based on particle size, percentage entrapment efficiency, and in-vitro drug release. The optimized F3 formulation exhibited a particle size of 179 nm, an entrapment efficiency of 96.1%, and an in-vitro drug release of 97.17% at 24 hours. Conclusion: The optimized Diacerin-loaded SLN formulation (F3) showed high entrapment efficiency, nanoscale size, and sustained drug release over 24 hours. It remained stable for three months under various storage conditions. These results suggest SLNs as a promising approach to enhance the oral bioavailability of Diacerin. Keywords: Solid lipid nanoparticles, hot homogenization, particle size, entrapment efficiency, in-vitro release
Publication date: 01/07/2025

https://ijbpas.com/pdf/2025/July/MS_IJBPAS_2025_9275.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.7.9275