ABSTRACT

The primary goal of this study was to formulate and assess an anti-inflammatory cream containing Guggul and Boswellia gums.10 grams of guggul (Commiphora wightii) and Boswellia (Boswellia serrate) gums were separately extracted using maceration with water and two types of oil (olive oil and sesame oil). The resulting oil and water extracts were then used to prepare two anti-inflammatory creams, formula 1 and formula 2. The anti-inflammatory activity by utilizing albumin denaturation method and the physicochemical properties of the prepared creams were analysed.Various parameters were examined to study the physicochemical properties of both creams. It was found that formula-I exhibited superior physicochemical properties. The anti-inflammatory activity was evaluated using samples and a standard drug at concentrations of 100?g/ml, 200?g/ml, 300?g/ml, and 400?g/ml. Interestingly, both Guggul and Boswellia shows anti-inflammatory activity equivalent to the standard drug diclofenac sodium.The results suggest that the utilization of Guggul and Boswellia in an anti-inflammatory cream is advised for the management of different inflammatory conditions. Keywords:Commiphora wightii, Boswellia serrate, maceration, wet gum method, anti- inflammatory, albumin denaturation
Publication date: 01/07/2025

https://ijbpas.com/pdf/2025/July/MS_IJBPAS_2025_9227.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.7.9227