ABSTRACT

One of the most suitable approach for achieving prolonged and predictable drug delivery profile in GI tract is gastroretentive drug delivery system. Floating pulsatile drug delivery system intended for chronopharmacotherapy is widely used for disease which shows circadian variation. It was applied to increase gastric residence of dosage form having lag phase followed by burst release. Aceclofenac is most suitable model drug for rheumatoid arthritis, osteoarthritis, pain and inflammatory conditions. Excipients were characterized for given specification. Binary mixture of Aceclofenac and polymers were prepared and evaluated for compatibility. Result of DSC thermogram and IR spectra shows drug:polymers are compatible with each other. Triple layer tablet was prepared using hydrophilic polymer as bottom layer and hydrophobic polymer as top layer. Tablet in Tablet of F23, F26 and F30 formulations shows 8 h floating with pulsatile release pattern. These three formulations were evaluated for micromeritics and physicochemical parameters, all parameters were found within acceptable range. Selected formulations of tablet in tablets were evaluated for buoyancy and drug release pattern. The polymer level have significant role for providing buoyancy and pulsatile release pattern. Keywords: Tablet in tablet, Gastroretentive, floating, Pulsatile, Aceclofenac
Publication date: 01/07/2025

https://ijbpas.com/pdf/2025/July/MS_IJBPAS_2025_9138.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.7.9138