ABSTRACT

On a worldwide scale, cancer has become a more prevalent cause related to mortality and morbidity. Enzyme therapies are becoming more widely used in medicine today, with numerous advantages in the treatment of diseases. Methionine amino acid plays a significant role in tumor cells. Methionine dependency of these cells ultimately results in apoptosis due to methionine limitation in tumor cells. Methionine amino acid has the potential to be used against several types of cancers. L-methionase is a microbial enzyme that has great therapeutic value as a potent anticancer agent against various types of tumor cell lines, including breast, lung, colon, kidney, glioblastoma, and neuroblastoma. The elimination of methionine is catalyzed by the L-Methionase enzyme, which results in the formation of ?-ketobutyrate, methanethiol, and ammonia. L-methionine is absent in mammalian systems, but it is present intracellularly in bacteria and extracellularly in fungi. Methionine restriction can be beneficial in improving the effectiveness of chemotherapy by inhibiting the proliferation of tumor cells. Methionine is an essential amino acid that is involved in several significant functions in mammalian metabolism, such as the synthesis of proteins, the methylation of DNA, and polyamines. Methionine also plays an indispensable role in gene activation and inactivation due to methionine limitation in cancer cells. Therapeutic interventions for various cancers have been developed using L-Methionase by introducing recombinant proteins to deplete methionine, which is essential for the growth of cancer cells. The current focus of clinical trials is on the application of L-methionase and methionine restriction in combination with chemotherapeutic regimens. Keywords: L-Methionase, Anticancer Enzyme, Enzymes Therapy, Methionine Restriction
Publication date: 01/06/2025

https://ijbpas.com/pdf/2025/June/MS_IJBPAS_2025_9134.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.6.9134