ABSTRACT

Telmisartan, a BCS class II antihypertensive drug has been indicated for treatment of Hypertension. To enhance the onset of action and solubility characteristics of Telmisartan, an effort was made to formulate mouth dissolving tablets (MDT) using natural super disintegrant. The main objective of the current investigation is to study the applicability of peanut shell powder (PSP) as super disintegrant. MDT of Telmisartan were prepared using various concentration of PSP using direct compression technique and evaluated for the physical tableting properties post compression, in vitro drug release, FTIR and stability studies. The results of the investigation indicate that the incorporation of PSP as a super disintegrant significantly reduces the disintegration time of Telmisartan MDTs compared to conventional formulations. Moreover, dissolution studies reveal improved drug release profiles, suggesting enhanced bioavailability and potentially better therapeutic outcomes due to swelling and water absorption properties of PSP. FTIR studies showed absence of significant drug excipient interaction. Accelerated stability studies on optimized formulation indicated stability of formulation. Keywords: Peanut Shell Powder, Super disintegrant, Telmisartan, Mouth Dissolving Tablets, Pharmaceutical Formulation
Publication date: 01/06/2025

https://ijbpas.com/pdf/2025/June/MS_IJBPAS_2025_9116.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.6.9116