ABSTRACT

This review presents a comprehensive analysis of buccal mucoadhesive tablets prepared using Quality by Design (QbD) principles, integrating both recent advancements and past literature findings. Buccal mucoadhesive tablets offer a promising drug delivery platform characterized by enhanced bioavailability, prolonged drug release, and improved patient compliance. Through a systematic review of the literature, this study examines the application of QbD methodologies in the design, formulation, and optimization of buccal mucoadhesive tablets. Critical quality attributes (CQAs) and critical process parameters (CPPs) relevant to buccal tablet formulation are identified and discussed in the context of QbD. Furthermore, the review explores the utilization of various analytical techniques and mathematical modeling approaches to establish correlations between formulation variables, manufacturing processes, and product performance. Challenges such as mucoadhesion strength, drug release kinetics, and formulation stability are addressed within the QbD framework, emphasizing the importance of understanding and controlling these parameters to guarantee the standard of the product and performance consistency. By synthesizing insights from past literature and recent developments, this review provides valuable guidance for researchers and pharmaceutical scientists in the rational design and optimization of buccal mucoadhesive tablets using QbD approaches. Keywords: Buccal drug delivery, Formulation, mucoadhesion, Optimization, Release
Publication date: 01/06/2025

https://ijbpas.com/pdf/2025/June/MS_IJBPAS_2025_9094.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.6.9094