ABSTRACT

Self micro-emulsifying drug delivery systems (SMEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SMEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to produce microemulsions or fine oil-in-water (o/w) emulsions after moderate stirring and dilution by water phase along the GI tract might be a promising technique for lipophilic agents with dissolution rate- limited absorption. By integrating suitable polymer into the formulation, SMEDDS maybe studied for the creation of a formulation with sustained drug release. This technology's improvement might lead to a newapplication in the field of medicine delivery. SMEDDS has been demonstrated to be quite efficient in increasing oral bioavailability of lipophilic products. SMEDDS is one of the promising methods for controlling the characteristics of medications that are not great choices for oral delivery . It is also worth mentioning that SMEDDS may be made invariety of solid dosage forms that are acceptable for both oral and parenteral administration. Oral delivery of many proteins and medical peptides is limited. Due to the GI tract's enzymatic and absorption membrane limitation, technologies have been investigated to solve these obstacles. SMEDDS from the last few years have acquired much interest as prospective carriers for oral peptide and protein administration . This review provides an outline of SMEDDS's numerous advances and biopharmaceutical elements, types, manufacturing, characterization, limitations, and future prospects. The evaluation of SMEDDS and its applicationsare also discussed, focusing on the advances of SMEDDS's solid self micro-emulsifying delivery mechanism and dosage form. Keywords: SMEDDS, Solubility enhancement, L-SMEDDS, S-SMEDDS, lipid based Oral delivery
Publication date: 01/06/2025

https://ijbpas.com/pdf/2025/June/MS_IJBPAS_2025_9039.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.6.9039