ABSTRACT

The aim of this research work is to evaluate the pharmacological potentials of the Azima tetracantha. The agar diffusion method was used to examine the antibacterial activity of different solvent extracts of Azima tetracantha tested against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. For qualitative phytochemical investigation, several solvent extracts of the complete A. tetracantha plant were investigated. The minimum inhibitory concentration (MIC) of M. spicata ethanol extract had significant antimicrobial effectiveness against Escherichia coli (480 ?g/ml), and Pseudomonas aeruginosa (430 ?g/ml). The ethanolic extract showed (425 ?g/ml and 395 ?g/ml) antimicrobial activity against Bacillus subtilis and Staphylococcus aureus respectively. The lowest antibacterial activity was found in acetone extract with MIC (206?g/ml) of A. tetracantha. Various parts of the plant have the presence of variety of phytoconstituents such as flavonoids, saponins, tannins, terpenes, steroids, amino acids, essential oil, polysaccharides and pectin. Keywords: Azima tetracantha, antimicrobial activity, agar diffusion method, Phytochemical analysis
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_9063.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.9063