ABSTRACT

The current study performed was to understand the anti-obesity potential of raw and ripe banana peels (Musa paradisiaca L.). The Musa paradisiaca L. is well known as banana. The fruits and peels contain rich nutrients and dietary sources. The Raw and ripe banana was collected, dried and the peel were macerate by using solvent and further separated by using rotatory evaporator. Lipase inhibition assay was conducted at the absorbance 400nm to obtained inhibition of enzymes. ?- amylase assay was conducted to determine the inhibition activity and anti-diabetic properties at the absorbance of 540nm.The lipid accumulation was determined at the absorbance of 510nm by the Oil red O method. An MTT assay was executed to determine whether the extracts were toxic or non-toxic to the 3T3 adipocyte cell line with an absorbance of 492nm and achieved cell viability. Lipase inhibition also exhibited anti-obesity property; methanol ripe extract showed 74.7% inhibition at the concentration 500?g/ml. The ?- amylase inhibition assay exhibited that methanol raw and ripe both extracts showed 91.4 and 91% inhibition at the concentration of 250?g/ml. The isopropyl raw extract inhibited highest lipid accumulation and adipogenesis during adipocyte differentiation as compared with absorbance of control. The results obtained through MTT assay showed that the raw and ripe banana peel extract is harmless to the 3T3 cells at the concentration ranging from 20?g/ml to 100?g/ml. The percent of cell viability obtained was 97.06% to 63.07% the result of present study depicts the ant obesity potential of ripe and raw banana peels. The peel contains rich dietary sources and high content of phytochemicals.Which are known to exhibit medicinal properties. Thus, the study indicates the potential of ripe isopropyl and raw and ripe peel methanol extract as ant obesity agents which can be further studied. Keywords: Musa paradisiaca L, anti-obesity, banana peels, phytochemicals and peel methanol extract
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_9046.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.9046