ABSTRACT

In the present study an attempt was made to prepare spherical agglomerates of Irbesartan, a BCS class II to improve its physicochemical and bulk properties. Irbesartan spherical agglomerates were prepared by solvent change method. It involves good solvent, poor solvent and bridging liquid dimethylformamide (DMF), water, toluene respectively.The prepared spherical agglomerates were evaluated for micromeritic properties (bulk density,tapped density, angle of repose, Hausner's ratio, and Carr's index). The agglomerates were characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM), solubilityandparticle size. The results of micromeritic studies suggested that the agglomerates showed improved flow properties due to spherical shape and bigger size of agglomerates. The FTIR studies indicated that there is no strong interaction at molecular level. PXRD results suggested that no alteration in the crystal structure of Irbesartan, but the crystallinity being modified. Spherical agglomerates of Irbesartan showed increased solubility and higher dissolution rate compared to Irbesartan. Keywords: Spherical agglomerates, FTIR, PXRD, Crystallinity, Solubility
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_9016.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.9016