ABSTRACT

Background: Lindernia ciliata (Colsm.) Pennell (Family: Linderniaceae) is mostly a weed found in Asia's tropics and subtropics. It is used traditionally by the common people of Assam for different ailments. Aim: We evaluated the acute oral toxicity of fractions of hydroalcoholic extracts of L. ciliata in female rats. Method: We used the percolation method to prepare hydroalcoholic extract using 80% ethanol and fractionated with petroleum-ether, chloroform, ethanol and water. The toxicity assay was performed as per OECD guidelines. During the study (2 weeks), we monitored the body weight and animal behaviour after test dose administration (2000 mg/kg body weight). After the experimental period, we collected the blood samples and evaluated the haematological profile, lipid profile, liver function test and kidney function test. We performed histopathological studies of vital organs. Results: The results suggested no significant changes in haematological profile, lipid profile, liver function test, kidney function test or histology of vital organs in test groups as compared to the control. Conclusion: Therefore, we concluded, hydroalcoholic extract fractions of L. ciliata (up to 2000mg/kg) produced no acute toxicity after oral administration. Keywords: Lindernia ciliata; Oral acute toxicity studies; OECD; Limit test; LD50;
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_8994.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.8994