ABSTRACT

Liposomes have wide range of applications in pharmaceutical and biotechnology. To eliminate the adverse effects associated with conventional treatments, smart nanostructured materials can deliver medications to the intended site with reduced dosage frequency and in a (spatial/temporal) controlled manner. Topical therapy in dermatology has improved due to liposomal carriers' ability to deliver active agents to the skin. The motivation behind interest in these carriers is their capacity to transport different biological materials to different cell types and to enclose them. These benefits include reduced risk of toxicity and side effects (because of the high topical concentrations of drugs); longer retention of high drug loads at the site of action and controlled drug release, guaranteeing prolonged therapeutic effect; and enhanced protection of drugs from potentially harsh environments at the site of action. They specifically enable overcoming the most important problems with conventional pharmaceutical therapies, including nonspecific distribution, fast clearance, unpredictable drug release, and inadequate bioavailability. Liposomes are nanoparticle drug-delivery systems that can release the drug in response to particular physiological signals, at the right time, and at the right target place. Smart nanoparticles are those that combine all two delivery methods: targeting that is passive targeting and active targeting. In this review paper applications of liposomes are specified and also their role as smart nanoparticles is clearly defined. Keyword: Liposome, Nanocarrier, Skin, Nanoparticle, Targeted drug delivery
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_8987.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.8987