ABSTRACT

The poor bioavailability of several drugs have been a major problem therefore we need to increase the amount of dose in order to get desired bioavailability and that sometimes lead to drug toxicity. To increase the efficacy or bioavailability of drugs herbal bioenhancers are majorly preferred. The bioenhancers are the substance or adjuvants who increases the bioavailbility of drug without showing their own therapeutic response, in regard to this herbal bioenhancers have shown the impressive response by enhancing the bioavailability through the chief mechanism of outlawing p-glycoprotein, outlawing CYP-450 enzyme or by enhancing the rate of absorption. Many herbal bioenhancer such as piperine, curcumin, niaziridin, etc have increased the bioavailability of drug. Keywords: Bioenhancer, Herbal Bioenhancer, P-glycoprotein, CYP-450, Absorption
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_8986.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.8986