ABSTRACT

This research aims to establish an UV-Visible spectroscopic technique for Hydroxyzine by applying a multivariate regression equation that is precise, sensible, and reproducible method. Proposed technique depends on the equation of the linear regression performed by taking absorbance at five distinct wavelengths. Hydroxyzine maximum absorbance was obtained at 230nm using distilled water as the solvent. Graph obtained from concentration 7-13?g mL-1 resulted in linear curve and the regression coefficient was obtained as 0.9999. % RSD values for Intra-day, as well as Inter-day precision, was obtained as 1.057624 and 1.361254. The assay value determined was between 99.78% - 99.90% w/w. Keywords: Hydroxyzine, sedative agent, UV spectrophotometry, Multivariate calibration, Assay, ICH guidelines
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_8985.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.8985