ABSTRACT

Rubiaceae plants, specifically ophiorrhiza plants, are used for healing in traditional and modern medicine. Recently, Ophiorrhiza recurvipetala was discovered in Assam, India. The scientific data supporting its potential to aid with health issues is scant. The LC-MS profile and anticancer activity of Ophiorrhiza recurvipetala aversion on oral squamous carcinoma cell lines (OSCC) were investigated using MTT assay. Fifteen compounds were found in LC-MS analysis, including quercetin, beta-sitosterol, camptothecin, and betulinic acid and etc., The IC50 of 264?g/ml demonstrated a considerable anti-cancer impact of the extracts on oral SCC. Ophiorrhiza recurvipetala extract bioactive ingredients analysed in LC-MS prevented oral SCC, as demonstrated by MTT. Based on these findings, Ophiorrhiza recurvipetala warrants further investigation for potential medicinal applications as a potential source of naturally occurring chemicals that combat cancer. Keywords: Ophiorrhiza recurvipetala, OSCC, LC-MS, MTT, IC50
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_8945.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.8945