ABSTRACT

A major part in drug therapy is contributed by the oral route of drug administration which has a high turnover rate in the pharmaceutical research and development sector. Nevertheless, obtaining a dosage form with sufficient bioavailability for weakly water-soluble drugs, (BCS classes II and IV) presents considerable hurdles. To overcome the limited bioavailability of poorly soluble pharmaceuticals, amorphous solid dispersions (ASDs) are one of several potential techniques that will increase the pace and extent of dissolution. Various analytical methodologies are being utilized to investigate the efficacy of ASDSs in increasing the bioavailability of hydrophobic medicines when compared to standard drug delivery methods. It is regarded as a significant method of increasing an active medicinal ingredient's perceived solubility. Physical and chemical features of ASDs are complicated. As a result, effective characterization procedures are required for the creation of ASDs. This study focuses mostly on commonly used methodologies for identifying ASDs and examining their procedures, implementations, advantages, and downsides. Keywords: ASDs, Bioavailability, Characterization, Dissolution, BCS
Publication date: 01/05/2025

https://ijbpas.com/pdf/2025/May/MS_IJBPAS_2025_8881.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.5.8881