ABSTRACT

Solubility refers to the process of a solid dissolving in a liquid phase to create a uniform system. This property is a critical factor in achieving the desired drug concentration in the systemic circulation for the manifestation of pharmacological responses. Drugs with poor water solubility often necessitate elevated doses to attain therapeutic plasma concentrations post oral administration. The primary challenge in formulating new chemical entities lies in overcoming low aqueous solubility. To facilitate absorption, it is imperative for a drug to exist in the form of an aqueous solution at the absorption site. Water stands out as the preferred solvent for liquid pharmaceutical formulations. Many drugs are weakly acidic or weakly basic with limited aqueous solubility, diverse techniques, such as micronization, chemical modification, pH adjustment, solid dispersion, complexation, co-solvency, micellar solubilization, and hydrotropy, are employed to enhance the solubility of poorly water-soluble drugs. The objective of this review article is to elucidate the various solubilization techniques, aiming to achieve effective absorption and heightened bioavailability Keywords: Solubility, Solubility enhancement, Co-solvent, pH, Emulsion
Publication date: 01/04/2025

https://ijbpas.com/pdf/2025/April/MS_IJBPAS_2025_8878.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.4.8878