ABSTRACT

Ethanolic extracts from the leaves of C. gigantean and A. aspera were assessed at doses of 300 and 300 mg/kg and combination (C. gigantean, A. aspera dose of 300+150 mg/kg) for anti- inflammatory effects using both acute and chronic inflammatory models. It was found that the doses possessed inhibitory effects on the acute phase of inflammation as seen in carrageenan- induced paw edema as well as in a subacute study of cotton pellet-induced granuloma formation. The anti-inflammatory activity elicited by the both plants ethanolic leaves extracts may be due to the influence of the active constituents such as beta-sitosterol and stigmasterol. A possible mechanism may also be due to the inhibition of prostaglandin synthesis which is also evidenced by the delay in the formation of wet faeces. Further study is required to postulate the exact molecular mechanism involved in this process of inhibition of inflammation by these leaves extracts. Keywords: Calotropis gigantean, Achyranthes aspera, anti-inflammatory, cotton pellet, paw edema
Publication date: 01/04/2025

https://ijbpas.com/pdf/2025/April/MS_IJBPAS_2025_8840.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.4.8840