ABSTRACT

An ulcer is a discontinuity of an epithelial surface (skin or mucous membrane). Chronic non healing ulcers are the wounds that fail to heal, in general they have a fibrotic margin and a bed of granulation tissue which may include areas of slough (necrotic tissue). Although the healing of the vrana is a natural process in the body, it can be delayed due to the Dosha dushti and due to krimi (microorganisms). The definition of Vrana implies the damage of a part of the body leading to discoloration. Hence, for early and uncomplicated healing of Vrana, local treatment should give utmost importance along with oral medications. Once the healing of the Ulcers is initiated, then the area should be kept free from further ulcerations. The symptoms of Dushta vrana mentioned by Acharya Susruta are analogous with that of Non-healing Ulcer. In the current study, the action of alcoholic extract of Kampillaka (Mallotus philippensis) against pathogenic bacteria like Staphylococcus spp., Pseudomonas spp. and Escherichia coli is evaluated in the pus of subjects diagnosed with Dushtavrana (Non-healing ulcer)by culture and sensitivity. With the current study, it is evident that the mean zone of inhibition of alcoholic extract of Kampillaka possesses anti-microbial action against the bacterium Staphylococcus spp., Pseudomonasspp., and E. coli. Further, it is also obvious that as the concentration of alcoholic extract of Kampillaka decreases, the zone of inhibition increases. Keywords: Non-healing ulcer, Dushtavrana, Kampillaka, Pus culture and sensitivity, Staphylococcus spp., Pseudomonas spp., Escherichia coli
Publication date: 01/04/2025

https://ijbpas.com/pdf/2025/April/MS_IJBPAS_2025_8243.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.4.8243