ABSTRACT

Azithromycin is a widely used antibiotic for treating skin conditions such as acne vulgaris, psoriasis, ocular infections, and rosacea fulminans. However, oral administration of azithromycin is often associated with various side effects. To avoid these, a topical emulgel formulation is an ideal alternative. As azithromycin is hydrophobic and does not dissolve easily in aqueous solutions, an emulsion-based approach is employed to enable its topical application. In this approach, azithromycin can be solubilized in light liquid paraffin, which facilitates the effective delivery of this hydrophobic drug. Additionally, research shows that Carbopol 971P forms a loosely compacted polymer matrix, enhancing the release of the drug, while Carbopol 974P contributes to improving the formulation's viscosity. Keywords: Azithromycin, Carbopol 974P, Emulgel, Topical Drug Delivery, antibiotic
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1048.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1048