ABSTRACT

The purpose of this research is to screen the wound healing ability of a hydro-alcoholic extract of Moringa oleifera leaves. Moringa oleifera is frequently used to treat wide variety of skin conditions in the Ayurvedic medicine system, as well as it is also used as folk medicine in wound management. Beside this, the Moringa oleifera has proven scientifically for its anti-microbial, anti-oxidant, and anti-inflammatory activity. So, it can be assumed that Moringa oleifera may show potent wound healing activity as the three most important related activities (anti-microbial, anti-oxidant, and anti-inflammatory activity) has already been proved. Moringa oleifera leaves were subjected for maceration by using 70% ethanol. Two different (2.5% and 5%) doses of Moringa oleifera gel formulation was prepared with HPMC (gel base) to apply topically. Evaluation of ability for healing from wound was done by “Excision, and Incision wound” models. In the excision wound model, Moringa oleifera treated rats showed a significant improve the epithelization time and 50% wound contraction. likewise, in contrast to the control group, the ratsthat received the extract of Moringa oleifera leaves exhibited a significant rise in breaking strength in an incision wound model. Moringa oleifera leaves hydroalcoholic extract gel formulations shown likely similar activities as compared to synthetic standard/marketed povidone-iodine as well as herbal standard Aloe vera gel It can be concluded that Moringa oleifera leaves 70% ethanolic extract (2.5 % and 5% gel formulation) has potent wound healing activity. Keywords: Moringa oleifera, Hydroalcoholic extract, Povidone-iodine, Aloe vera, Wound healing activity
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1045.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1045