ABSTRACT

Employing 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis, we examined how Mosinone-A affected the expression of apoptosis-related proteins. Four groups of ten golden Syrian hamsters each were randomly selected. The untreated controls were animals in Group I. For 14 weeks, Groups II and III's animals received three weekly treatments having 0.5 percent DMBA in liquid paraffin solution on their left cheeks. Starting one week prior to their exposure to the carcinogen, Group III animals received oral doses of Mosinone-A (2 mg/kg body weight). Until the animals were slaughtered, this medication was given on days when no DMBA application had been planned. For the length of the experiment, the animals in group IV were given only Mosinone-A. Cheek pouch carcinomas became apparent following 14 weeks of topical DMBA treatment, together with decreased expression of P12DOC- 1, p16INK4A, as well as p15INK4B. Consuming Mosinone-A orally significantly suppressed HBP carcinoma formation as evidenced by overexpression of these genes. The current research's findings indicate that Mosinone-A may have preventive effect against development of DMBA-induced cheek pouchcancer. This effect appears to be mediated by its ability to inhibit cell proliferation, induce apoptosis, AS WELL AS promote cellular differentiation, thereby exerting its anti-cancer potential. Keywords: Mosinone-A, Cell cycle proteins, Oral cancer, apoptosis, DMBA, RT-PCR
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1040.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1040