ABSTRACT

Microorganisms have developed resistance to many available therapeutic agents through various protective mechanisms in order to counteract the harmful effects of antibiotics, thus eventually resulting in loss of inhibitory potential of antibiotics. The phenomenon of multidrug resistance among the bacterial pathogens particularly in ESKAPE pathogens poses a major risk to the human health. The ESKAPE term includes 6 pathogens - Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. The looming health threat caused by these pathogens causing Hospital acquired infections and the demand for better patient care has stimulated interest for understanding the mechanisms of drug resistance acquired by these pathogens and the improvement of therapy through novel drugs. Hence there is an urgent need to focus research to develop various strategies in order to overcome their drug resistance and to discover new antibiotics that act against ESKAPE pathogens. This review paper gives an overviewof ESKAPE pathogens and their prevalence at global level and discusses their drug resistance mechanisms and various strategies employed to combat ESKAPE pathogens. Keywords: ESKAPE pathogens, antimicrobial resistance, AMR Surveillance, multidrug resistance, Hospital Acquired Infections
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1026.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.3.1026