ABSTRACT

Aphthous ulcers (AUs), commonly known as canker sores, are painful, recurrent lesions that affect the oral mucosa, causing significant discomfort and impacting the quality of life. Traditional treatments for aphthous ulcers, such as topical ointments, oral medications, and antiseptic mouthwashes, often fail to provide sustained relief and require frequent application. In recent years,in-situ gel systems have gained attention as a promising strategy for the localized and controlled treatment of aphthous ulcers. These gels are designed to transition from a liquid to a gel form upon contact with the mucosal surface, ensuring prolonged contact at the ulcer site. The gel's mucoadhesive properties enhance its therapeutic effects by increasing drug retention and bioavailability, promoting faster healing, and alleviating pain. Various active pharmaceutical ingredients, including corticosteroids, anti- inflammatory agents, and antimicrobial compounds, have been successfully incorporated into in-situ gels to target the underlying causes of ulceration and provide symptomatic relief. This review explores the potential of in-situ gel systems in the treatment of aphthous ulcers, highlighting their benefits such as ease of administration, localized action, and enhanced patient compliance. Keywords: In-situ gel, controlled release, anti-inflammatory agent, antimicrobial agent, Patient compliance
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1015.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1015