ABSTRACT

Psoriasis is a chronic inflammatory skin condition that often necessitates long-term treatment, which can lead to undesirable side effects when using synthetic drugs. This study focuses on the formulation and pharmacological evaluation of herbal cream for the treatment of psoriasis, employing natural excipients to mitigate such side effects. Herbal cream was developed using various natural gums and polymers. Compatibility between the herbal drug and excipients was confirmed through Fourier transform infrared (FTIR) spectroscopy. The formulations were evaluated for parameters such as drug content uniformity, viscosity, pH, and stability. Drug release studies were conducted using a dialysis membrane in phosphate buffer (pH 6.8) at 37°C, with the release kinetics best fitting the Higuchi model. Biological studies on albino mice revealed that formulations containing emulsifying wax and cetostearyl alcohol provided superior drug incorporation, with a drug activity rate of 43.3%. The anti-psoriatic activity was validated through enhanced orthokeratotic cell differentiation in the epidermal scales during mouse tail testing. The findings demonstrate the significant in vitro anti-psoriatic activity of the herbal cream formulation, supporting its efficacy in treating psoriasis while offering a natural and safer alternative to synthetic treatments. Keywords: Psoriasis; Azadirachta indica; Pongmia pinnate; Cassia tora; Cream; Soap; Drug content Uniformity; Biological studies
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1014.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1014