ABSTRACT

Graphene nanomaterials (GNMs) offer significant potential in drug delivery and biomedical applications due to their unique properties. Graphene oxide (GO), a derivative with oxygen functional groups, is particularly promising for diagnosing and treating brain disorders due to its biocompatibility and low cytotoxicity. The rise in neurological diseases, necessitates sophisticated drug-delivery capable of traversing the Blood-Brain-Barrier (BBB). This review comprehensively addresses the synthesis, characterization, and properties of various GNMs, with an emphasis on their applications in targeted drug delivery, bioimaging, gene therapy, regenerative medicine, and antibacterial activity. It covers synthesis methods, including the modified Hummer's method, and characterization techniques such as Raman spectroscopy, FTIR, XPS, AFM, SEM, and TEM. Furthermore, the review explores the electrical and mechanical properties of GNMs and their potential to enhance drug delivery through both covalent and non-covalent modifications. This review provides an overview of GNMs' potential in biomedical applications, emphasizing their role as drug delivery vectors and therapeutic agents, with ongoing research aiming to optimize their properties for clinical use. Keywords: Graphene nanomaterials (GNMs), Graphene oxide (GO), Blood-Brain-Barrier (BBB)
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1012.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.3.1012