ABSTRACT

In this study, female Wistar rats are used to test anti-ovulatory and contraceptive effects of talisadi yoga containing equal quantity of talispatra (Taxus baccata) and Gairika (red oxide) mentioned in ancient ayurvedic classics yogaratnakara. After acclimating to conventional laboratory conditions, the healthy Wistar albino rats weighing 200±20 g were chosen for the study and placed into three groups, with six animals in each group. Group I animals were treated with distilled water (10 ml/kg body weight) and were regarded as Controls. Group II received the test substance at a dose level of 1000 mg/kg b. wt. whereas Group III was treated with Primolut-N as a positive control. For 21 days in a row, the animals in each group received treatment with the appropriate chemical or vehicle. Every day prior to the compounds being administered, the vaginal smears of all the animals were produced. At the conclusion of the trial, body weight, blood serum levels of cholesterol, triglycerides, and total cholesterol were measured in each group. The ovary and uterus histopathology analyses of each group were also performed. At the end of study it is found that the oral administration of the test compound i.e. Talisadi yoga resulted in the inhibition of normal Estrous cycle of female Wistar albino rats suggesting its anti-ovulatory activity. Keywords: Antifertility; Contraceptive; Talisadi yoga; Yogratnakar; Ayurveda
Publication date: 15/03/2025

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https://doi.org/10.31032/IJBPAS/2025/14.3.1011