ABSTRACT

In this work we synthesized new isobutylphenyl-linked oxadiazole derivatives and evaluated the antimicrobial action of the synthesized molecules. The anti-microbial activity of the compounds was assessed against gram positive and gram negative bacteria and fungus. The zone of inhibition of each compounds was measured it was found that the compounds exhibited poor activity against gram negative bacteria compared to gram positive. The zone of inhibition suggested that compounds 5b and 5d were more potent in preventing microbial growth compared to the other compounds. The results of MIC study were similar to zone of inhibition and it was found that 5b had IC50 of 25?g/mL against all the tested microbes and 5d has IC50 of 50?g/mL against the tested microbes. The studies led to the conclusion that the synthesized compounds were having medium antimicrobial activity and the presence of electron withdrawing groups in the phenyl ring was beneficial for activity. A meta substituted electron withdrawing group was unable to present antimicrobial action (5c) and on the other hand an electron donating on ortho position (5e) was having better activity then the meta substituted compound with electron withdrawing group. Keywords: Isobutylphenyl, oxadiazole, antifungal, antibacterial, electron donating
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1004.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1004