ABSTRACT

Joint and muscle pain are distinct medical conditions in which, joint pain typically occurs at rest and muscle pain during the movement. Both significantly affect the quality of life. Nonsteroidal anti- inflammatory drugs (NSAIDs) are commonly used for the pain management. But, their prolonged use is associated with adverse effects, particularly gastrointestinal issues. Furthermore, increasing dosage requirements over time highlight the need for safer, more sustainable alternatives. This study focuses on the development of a ointment designed to alleviate pain, reduce inflammation, and support recovery and healing. The formulation incorporates methyl salicylate, a potent topical analgesic known for its anti-inflammatory properties; glucosamine sulfate, which promotes joint health and aids in cartilage repair; and sodium chloride, which helps maintain electrolyte balance, tissue hydration and relaxation enhancing the healing process. A systematic approach was adopted, in the selection of appropriate excipients and the optimization of key parameters such as pH, viscosity, spreadability, and homogeneity. Stability studies were conducted under different conditions to assess the product's shelf life and integrity. Additionally, analgesic and anti-inflammatory studies were performed to evaluate the efficacy of the formulation. The results show that this ointment formulation could be a good option for managing pain and treating inflammation. Keywords: Anti-inflammatory, joint pain, muscle pain, glucosamine sulphate, methyl salicylate, sodium chloride, pain management
Publication date: 15/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_MARCH_SPCL_1003.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.1003