ABSTRACT

Stand towards WHO (world health organization) third February 2024, the majority generally caused sarcoma in the wide-reaching is breast cancer and national breast cancer coalition states that, the prevalence of breast cancer is 1 in 8 also main risky sort is TNBC- triple negative cancer. Going on do research among a lot heterocyclic analogs, the quinazolinone be establish to be persuasive anti-breast cancer means also effectual alongside triple negative breast cancer(TNBC) such as MCF-7-Michigan cancer foundation-7MCF-7 cell lines, EGFR-Epidermal growth factor receptor, Vascular endothelial growth factor receptors also M.D. Anderson-Metastatic breast- 231(-MDA-MB-231) cell line and quinazolinone is dominant lactam-lactim tautomeric interface with existence of methyl cluster in the second place. In attendance, will be enhances in tautomeric effect. The structural activity relationship of quinazolin ring system states that position at 2nd, 6th and 8th are an immense important. The swop of phenyl ring at 8th position and nitro group situatein 6th place possess a realistic anti-cancer battle plus continuation of assorted heterocyclic moieties into position at 3rd which enhances chemotherapeutic action. Thus, quinazolinone is a promising scaffold intended for anti cancer possessions. These descriptors envelop the available effort resting on anti-breast cancer analogs entrenched in foregoing do research credentials commencing in progress revision. The belongings of innovative composite enclose an attractive anti-breast cancer influence to facilitate preserve exist safe. Keywords: Quinazolinone. Breast Cancer, EGFR, Scaffold, Anti-Cancer, Position, Tautomeric Effect
Publication date: 01/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_8843.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.8843