ABSTRACT

The solubility behaviour of the drug is still one of the most important aspects of formulation development. Nowadays, the number of new drugs is increasing, but they have problems of poor solubility and poor permeability. For drugs with poor water solubility, solid dispersions have become a better option than dosage forms. Solid dispersion within water-soluble carriers have attracted considerable attention as a way to improve the dissolution rate and bioavailability of hydrophobic drugs. Solid dispersion has the ability to increase the solubility of the drug. There are many ways to increase the solubility of new drugs in which solid dispersion are promising. Solid dispersions usually have two components - drug and polymer matrix. Number of methods are present to prepare the solid dispersions such as solvent evaporation method, melting method, spray drying method, fusion method, kneading method, co-grinding method, hot melt extrusion, melt agglomeration, lyophilization technique, supercritical fluid (SCF) technology etc. Various hydrophilic carriers have been investigated to enhance the solubility and bioavailability properties of poorly water-soluble drugs. Keywords: Solubility, Dissolution, Hydrophobic Drugs, Polymer, Carriers, Solid Dispersion
Publication date: 01/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_8825.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.8825