ABSTRACT

Aim: To evaluate the phytochemical profile and pharmacological potential of Ethanolic Extract of Cajanus cajan (EECC) and Hexane Extract of Cajanus cajan (HECC). Methods: 8–12-week male albino Wistar rats were used. Nicotinamide (NAD-100 mg/kg) was administered through Intraperitoneal (I.P) route. After 15 mins Streptozocin (STZ-50 mg/kg) was administered through I.P. route. After 72 hrs (3 days) rats showing FBGL (Fasting Blood Glucose Levels) of 230-330 mg/dl were considered as diabetic and divided into the groups as control (vehicle), diabetic control (STZ+NAD), standard (STZ+NAD+glibenclamide-0.5 mg/kg), Ethanolic Extract of Cajanus cajan leaves (EECC-500 mg/kg), Hexane Extract of Cajanus cajan leaves (HECC-500 mg/kg). Results: EECC & HECC consists of high number of flavonoids (20.21% and 30.95%) and phenols (14.98% and 18.57%). OGTT (Oral glucose tolerance test) was performed, the maximum reduction of blood glucose levels by standard (54.26%), EECC (23.19%) and HECC (41.09%) was seen at 120 mins. Conclusion: These results shown that the EECC and HECC were able to produce glucose tolerance and hypoglycemic action. Keywords: Cajanus cajan, Flavonoids, Phenols, OGTT, blood glucose levels
Publication date: 01/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_8821.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.3.8821