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Synthesis and Antibiotic Activity of 1-(2-Fluorphenyl)-5-phenyl-1H- tetrazole and 1-(2-chlorophenyl)-5-phenyl-1H-tetrazole(1,5-disubstituted Tetrazoles) catalyzed by EuFOD
Authors: G. Nageswara Rao* And M. Rajeshwari

ABSTRACT
Synthesis and Antibiotic Activity of 1, 5-disubstituted Tetrazoles in 84–85% yields using EuFOD in the presence of sodium azide and acetonitrile as solvent with EuFOD (Europium(3+)tris [(3Z)- 6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-5-oxo-3-octen-3-olate]), Sodium Azide was used as an azide transfer reagent as it transformed the amide to an imidoyl azide intermediate and, then, by ring closing, to tetrazole. The formation of hindered 1, 5-disubstituted tetrazoles was confirmed by 1H-, 13C-, and 19F-NMR, HRMS, and FT-IR. Keywords: 1, 5-Disubstituted tetrazoles, EuFOD and Sodium Azide, Acetonitrile, N- benzoyl amide
Publication date: 01/03/2025
    https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_8818.pdf
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https://doi.org/10.31032/IJBPAS/2025/14.3.8818

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