ABSTRACT

The rationale of writing this review on Hydrodynamically Balanced drug delivery system (FDDS) was to assemble current literature with unique center of attention on the role of Natural Polymers in flotation to attain gastric retardation. Mouth drug delivery system is the majority preferential Course of management for drug delivery system of several components participate crucial function. In current existence, diverse scientists were put their efforts to found more advancements in their investigation and develop a release restricted oral drug delivery system to conquer the difficulties such as low gastric residence time, impulsive gastric emptying time. To conquer these difficulties gastroretentive drug delivery system was established which has the capability to hold the drug release in stomach in favor of larger time and there by enhances the availability of drug in plasma, conceivably it provides therapeutically efficient plasma drug concentration for longer period of time, in so reducing doing frequency and increasing the bioavailability. In current scenario major researchers will focuses on applications of natural gums. Natural polymers and their compounds are frequently utilized to create different dosage forms for pharmaceuticals than synthetic polymers because they are readily available, inexpensive, biodegradable, and non-toxic. By extending the dose form's retention period in the stomach, the gastric floating drug delivery method increases the medicine's oral bioavailability. This review has talk about applications of some recently investigated gums in FDDS approaches such as low-density system, high density system, mucoadhesive system, swellable system. Keywords: FDDS, Natural gums, SiteSpecific Drug Delivery, Gastric Retention, Hydrodynamically balanced systems
Publication date: 01/03/2025

https://ijbpas.com/pdf/2025/March/MS_IJBPAS_2025_8783.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.3.8783