ABSTRACT

Breast cancer is a condition where malformed breast cells proliferate and develop into tumours. Tumours can become deadly if they proliferate throughout the body and are not treated. So, this study explores the synergistic anti-cancer activity derived from the combination of Catharanthus roseus (commonly known as Madagascar periwinkle), a plant source of vinblastine and vincristine, potent anti-cancer alkaloids, with Solanum lycopersicum (tomato), a rich reservoir of lycopene, a recognized anti-cancer pigment. The rationale behind this investigation lies in the potential enhancement of anti-cancer effects through the complementary action of these bioactive compounds. The research involves extraction of Catharanthus roseus and Solanum lycopersicumin in respective solvents. Subsequently, combined ratio of both plant extract are subjected to evaluate for synergistic activity on breast cancer cell lines. Preliminary findings indicate a notable increase in anti-cancer activity when combined chemical constituent from both extract which is more prone for anticancer activity, suggesting a synergistic interaction. This synergy may be attributed to complementary mechanisms of action to achieve hypothesis. Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone for cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in a characteristicallysynergistic or an additive manner. This approach potentially reduces drug resistance, while simultaneously providing therapeutic anti-cancer benefits, such as reducing tumour growth and metastatic potential, arresting mitotically active cells, reducing cancer stem cell populations, and inducing apoptosis. Keywords: Catharanthus Roseus Linn., Solanum Lycopersicum Linn., lycopene, vincristine, vinblastine, synergistic anticancer activity
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8766.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.2.8766