ABSTRACT

Background: Azithromycin, a drug of macrolide groups, gives clinical benefits to the several pathogenic bacterial infected patients. Beyond a lot of good clinical insights, it possesses some catastrophic impact on human health. Specially, during the period of COVID this drug was used in a boundless manner which might have some impact on gut flora. Aim: Thus, our study is aimed to find out those severity after the exposure of azithromycin. Methodology: Ten, eight weeks old male albino rats were obtained having 150-160g body weight. They were grouped into two (n=5), viz. control and treated. Treated group received Azithromycin at a dose of 33mg/kg/day for 14 consecutive days. Then fecal parameters, gut motility and total bacterial colony count were measured from both groups, followed by statistical analysis of the previously mentioned parameters. Results and conclusion: Decreased fecal frequency and increased fecal water content were found after the Azithromycinexposure. The irregularity of gut motility and increased transit time were seen in the treated rats. Decreased total bacterial colony count was also found in both fecal and small intestinal tissue samples after the treatment. Impairment of gastrointestinal system and related gut microbial dysbiosis after azithromycin exposure can be concluded after this entire study. Keywords: Gastrointestinal system; gut bacteria, gut motility; Gastrointestinal system; GI transit; colonic transit
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8747.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.2.8747