ABSTRACT

Alzheimer is a neurological disease that causes memory loss and a steady decline in cognitive function. According to WHO Alzheimer’s disease is estimated from 74.4 million in 2023 to 152.8 million cases in 2050. There are many hypotheses about the neurodegeneration process. Currently the availability of approved drugs for treating the Alzheimer’s disease, produced no effective pharmacological therapy for slowing, or reversing neurodegeneration. Due to the limitations of existing drugs, because of efficacy problems, adverse effects and toxicity there is an urgent need to develop new drug molecules to address these issues. The chemistry of Schiff base and Mannich base-containing compounds has been an interesting field of study in drug design and Development. As a result, these derivatives are a crucial class of molecules for developing a new chemical entity. Schiff and Mannich bases are an essential organic class of compounds with diverse biological activities. They exhibit a wide range of biological activities, including anti-microbial, anti-bacterial, anti-fungal, anti-viral,anti- convulsant, anti-Alzheimer activity etc. This review examines the extensive literature reports that have revealed the chemistry of different derivatives of substituted Schiff and Mannich bases as promising lead molecules for targeting various Alzheimer’disease pathologies over the past two decades. Hence it is a worthy review study to explore the biological importance of Schiff and Mannich base against Alzheimer’s disease. Keywords: Alzheimer’s disease, Schiff base, Mannich base, anti-microbial, anti- convulsant, anti-fungal
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8709.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.2.8709