ABSTRACT

Starting from simple analytical methods to the recent development of advanced technological stages, various analytical methods have been designed for the multicomponent analysis of drugs. Simultaneous estimation of drugs in the combined dosage form has proved vital in the pharmaceutical analysis since it is cost-effective and time-saving. Levocetirizine, the peripheral H1-receptor antagonist and R-enantiomer of Cetirizine, serves as a non-sedative antihistamine for the treatment of chronic idiopathic urticaria, angioedema, and allergic rhinitis. In the treatment of allergic rhinitis, the combination of Levocetirizine and Montelukast Sodium, a selective cysteinyl leukotriene I receptor inhibitor acting as an anti-asthmatic agent in the bronchial tubes and lungs, is commonly utilized. This pharmaceutical formulation has demonstrated added benefits in efficiently reducing symptoms for patients. Within this review article, various analytical methods applied to estimate Levocetirizine and Montelukast Sodium in their combined dosage form are compared and addressed. The methodologies encompass UV Spectrophotometry, High-Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), and High-Performance Thin-layer Chromatography (HPTLC). Furthermore, the article provides insights into the development of diverse analytical techniques for the estimation of Levocetirizine and Montelukast Sodium in conjunction with other drugs available in the market. The current paper recommends a suitable method for analyzing this pharmaceutical compound, contributing to the optimization of various analytical methods for their determination. Keywords: Levocetirizine, Montelukast Sodium, Allergic Rhinitis, Spectrophotometry, Chromatography
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8702.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.2.8702