ABSTRACT

Peptic ulcers are a common gastrointestinal disorder affecting millions of people worldwide. The main cause of peptic ulcers is the imbalance between the aggressive factors and the defensive factors in the stomach lining. Although there are several drugs available to treat peptic ulcers, prolonged use of these drugs can lead to several complications. Therefore, the use of plant-based drugs is gaining popularity as a safer alternative for treating peptic ulcers. This study employed the ethanol-induced method to evaluate the antiulcer activity of the ethanolic extract of Euphorbia milii Des Moul. Leaves in male Wistar albino rats. Euphorbia milii is a plant with several phytoconstituents that possess antioxidant, anti-inflammatory and mucus stimulating properties. In-vitro study was conducted using Fordtran’s titration model and the results showed that the plant extract possess acid neutralizing capacity. For the in-vivo study, absolute ethanol was used for the induction of ulcer. The parameters studied include volume of gastric juice secretion, total acidity, pH of gastric juice, ulcer index and percentage protection, the results of which showed that theplant extract could reduce the gastric juice secretion, total acidity, ulcer index and increase the pH of the gastic juice and percentage protection in a dose dependent manner. The histopathological studies were in support with these findings. Thus, the findings of this study showed that the ethanolic extract of Euphorbia milii leaves has significant antiulcer and antacid activity, making it a promising candidate for further investigation as a potential treatment for peptic ulcers. Keywords: peptic ulcer, Euphorbia milii, Antiulcer, Fordtran’s model, Absolute Ethanol
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8672.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.2.8672