ABSTRACT

Aim of present study was to investigate the preliminary screening of aerial part of Oxalis stricta extracts for liver Protective activity on experimental rats. Using In-vitro hepatoprotective Model, In this study practical study was started to evaluate anti-hepatic effects of Oxalis stricta linn on albino rats. The hepatoprotective effects of Ethanolic Extract of Oxalis stricta Linn. (EEOS) towards thioacetamide induced hepatic damage in Albino rats. The extracts of were prepared dose for 250 mg/kg and 500mg/kg against liver toxicity induced by thioacetamide at a dose of thioacetamide 100 mg/kg s.c. once daily. To evaluate some important hepatic parameters such as, Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and bilirubin content. Standard drug Silymarin (100 mg/kg) p.o. administered to albino rats was used as reference group. In thioacetamide treated animals shows lipid peroxidation was increased with decrease in superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) levels which represents the hepatic antioxidant status when compared with reference group. It was further confirmed by histopathological observations. From the results it may be concluded that the 70% ethanolic extract of Oxalis stricta Linn Possess hepatoprotective activity. Keywords: Oxalis stricta, Liver toxicity, Thioacetamide, Anti-oxidant, Silymarin
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8669.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.2.8669