ABSTRACT

Malaria is a life-threatening infectious disease caused by parasitic single-celled microorganisms, mainly transmitted by the anopheles female mosquito of the plasmodium family. Artemisinin, an antimalarial agent, is one of the cheaper drugs available worldwide. It has been observed that resistance toward artemisinin and some other quinine derivatives developed in the southeast region of Asia like Cambodia, Thailand, Myanmar, and Vietnam since 1957. Since 1970, the exact resistance has been increased, and it has been developed in several regions of India. Consequently, it is necessary to create some potential antimalarial agents to overcome this kind of drug resistance and side effects. Here we have reviewed research articles by the researchers from various countries and executed an attempt to report Plasmodium falciparum artemisinin resistance as a result of mutations in pfcrt and pfmdr1 gene. Keywords: Malaria, sepsis, gastroenteritis, Polymerase chain reaction, Resistance, Vacuolar transport
Publication date: 01/02/2025

https://ijbpas.com/pdf/2025/February/MS_IJBPAS_2025_8662.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.2.8662