ABSTRACT

Medicinal plants have long been a vital source used by humans for preventive and curative needs. However, there is always an urgent to more document these valuables indigenous knowledge. Hence, the current work aimed to identify the traditional therapeutic virtues of Spermacoce ocymoides (Burm. F.) and to evaluate its antioxidant and antimicrobial activities. Ethnobotanical data were collected through an open and semi-structured questions inside three villages in the commune of Dinandougou, Mali. Phytochemical composition was determined by qualitative and colorimetric tests. Antioxidant activity was assessed by DPPH radical and phosphomolybdate methods, and antimicrobial activity by agar diffusion. A total of 40 people were surveyed, with 60% of men and 40% women. These people mainly used the "stem-leaves" combination to treat various illnesses, topped by ringworm (54.93%), acne (29.58%) and infected wounds (9.86%). Recipes made from S. ocymoides were mostly prepared by trituration (56%) and administered through skin (97%). The highest levels of polyphenols (3.08±0.16 g EAG/100g), flavonoids (0.72±0.006 g EQ/100g) and tannins (1.11±0.03 g EAG/100g) were recorded with hydroethanolic extracts. These extracts also showed the best antioxidant potential with IC50 = 715.55±35.55 ?g/mL and the largest inhibition diameters (ID) on Staphylococcus aureus (ID = 22.67±0.58 mm) and Candida albicans (ID = 17.33±0.58 mm). This study shows that S. ocymoides extracts are rich in bioactive compounds and endowed with an appreciable antioxidant and antimicrobial potential. Keywords: Herbal medicine, Spermacoce ocymoides, antioxidant and antimicrobial activity
Publication date: 01/01/2025

https://ijbpas.com/pdf/2025/January/MS_IJBPAS_2025_9674.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.1.9674