ABSTRACT

Background: Karnasravahara Arka is formulation preparared by fresh leaves of Amra (Mangifera indica L), Jambu (Syzygium cumini L.), Madhuka (Madhuca indica J.F.Gmel) and Vata (Ficus benghalensis L.) which is indicated in Karnasrava (otitis externa) as ear drops. Aim: An attempt was made to develop a polyherbal ear drops (Karnasravahara Arka) and validate the same through analytical as well as in vitro antimicrobial study. Methodology: The raw drugs were authenticated through physicochemical, phyto chemical analysis and Gas chromatography–mass spectrometry (GCMS). Karnasravahara Arka was prepared in three batches and the samples were subjected for physico- chemical parameters and GCMS. In vitro study was carried out on organisms causing otitis externa. Results: Karnasravahara Arka can be effortlessly prepared as its ingredients are available in abundance as a natural habitat in the area of study. The ingredients of test drug show the predominance of Kashaya rasa. Preliminary phytochemical evaluation of raw drugs showed the presence of Alkaloids, Glycosides, Saponins, Flavonoids, Carbohydrates, Tannins, Proteins, and Steroids. GCMS of raw drugs indicates presence of many active principles with 15 peaks, the13,16-Octadecadiynoic acid, methyl ester was highest peak. However, the preclinical in-vitro antimicrobial study of this formulation on organisms causing otitis externa did not show any effect. Keywords: Arka kalpana, Polyherbal ear drops, Karnasrava, Distillation, Antimicrobial
Publication date: 01/01/2025

https://ijbpas.com/pdf/2025/January/MS_IJBPAS_2025_8647.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.1.8647