ABSTRACT

The use of medicines has been increased across the globe over the past century and continue to increase in the coming years due to the discovery of new treatments to cure recent diseases and various health disorders. Many pharmaceutical wastes are released into the environment by households, hospitals, and other activities. The unwanted drug disposal will be an issue in the landfill soil due to improper disintegration. Improperly handled pharmaceutical wastes will enter the landfills. Along with these wastes, some may subject for segregation and others may not. Based on the above concept, the current research has been done. To study the impact of expired tablets, a pilot study has been carried out to determine the impact of regularly discarded tablets on the landfill soils. For the study, expired Clonazepam tablet was used. This tablet was selected based on the survey carried on the types of pharmaceuticals disposed along with the households’ wastes. Also, organoleptic characterization of expired clonazepam tablet was conducted. During the present study, the expired clonazepam tablet was added at concentrations of 1g, 5g, and 10g to the landfill soil sample and kept for observations for 30 days. The soil samples were collected and subjected for extraction to analyse various physico-chemical parameters. From the study, it was observed that, the bulk density, particle density, water holding capacity and moisture content present in soil was higher than the normal range. The chemical parameters like phosphorus, calcium, magnesium, sulphate, available nitrogen and potassium values were found to be increase with the increase in the number of days and the clonazepam concentration. Keywords: Clonazepam Tablet, Expired Drug, Physico-chemical properties, Soil Quality
Publication date: 01/01/2025

https://ijbpas.com/pdf/2025/January/MS_IJBPAS_2025_8626.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.1.8626