Transdermal drug delivery systems (TDDS) have gained significant attention in the field of
pharmaceuticals due to their ability to provide a controlled and sustained release of drugs
through the skin, thereby bypassing the oral route and its associated challenges. The primary
objective of transdermal delivery is to enhance patient compliance by offering a non-invasive
and painless mode of drug administration. Various techniques, such as patches, gels, and
micro/nanoemulsions, have been developed to facilitate efficient drug permeation through the
skin barrier. This review highlights the mechanisms underlying transdermal drug delivery,
emphasizing the importance of formulation techniques, skin permeation enhancers, and the
selection of appropriate drug candidates. Additionally, the review discusses challenges related
to skin permeability, drug stability, and regulatory approval, underscoring the need for
continuous research and innovation in formulation technologies. Furthermore, the impact of
transdermal drug delivery on specific therapeutic areas, including pain management, hormone
replacement therapy, and cardiovascular diseases, is explored. Looking forward, this examines
emerging trends such as microneedle-based systems, smart patches, and personalized
transdermal therapies, providing a glimpse into the future of drug delivery. As TDDS continue
to evolve, they hold the promise of revolutionizing healthcare by improving patient outcomes,
ensuring precise drug dosing, and minimizing adverse effects, ultimately leading to enhanced
overall quality of life for patients.
Keywords: Sustained release, Non-invasive, Drug permeation, Pain management, Hormone replacement
Publication date: 01/01/2025
https://ijbpas.com/pdf/2025/January/MS_IJBPAS_2025_8596.pdf
Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.1.8596
