ABSTRACT

Objective: Valuable attention has been spent to genus Astragalus due to its biodiversity, phytoconstituents, economical and therapeutic benefits. The present study aims to investigate the chemical profile and biological activities of the Saudi population of Astragalus sieberi fruits growing in Northern Border Region. Materials and methods: Biological activities including Cytotoxic, antimicrobial activities, and antioxidant have been investigated. The phytochemical profiling, determination of total phenolic content (TPC) and total Flavonoid content (TFC) in addition to HPLC tracing of common flavonoids and phenolic acids have been also determined. Results: phytochemical screening revealed for the first time the presence of valuable phytoconstituents including phenolic compounds, flavonoids, triterpenes, alkaloids and saponins. The biological activity testing showed promising cytotoxic activities against all tested cancer celllines (HepG-2, HCT-116 andA-549), while no pronounced antimicrobial effects have been determined. Conclusion: For the first time, A. sieberi fruits have been investigated for their biological activity and chemical constituents. This study showed valuable phytoconstituents and promising cytotoxic activities, further investigation is recommended for this valuable natural sources. Keywords: Astragalus sieberi fruits, phytochemical profile, cytotoxic activities, antioxidant activity
Publication date: 01/12/2024

https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_9834.pdf

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https://doi.org/10.31032/IJBPAS/2024/13.12.9834