In this research, PLA (poly lactic acid) and kappa carrageenan were combined utilizing a
simple procedure that required combining their solutions and then crosslinking them with a
glutaraldehyde solution to create bioactive wound dressings. Various ratios of PLA to kappa
carrageenan, such as 80:20, 60:40, 70:30, and 50:50, were utilized, and the mechanical,
thermal, and swelling characteristics of the resultant films were assessed. These bandages for
wounds were created with biomedical uses in mind, specifically to aid in the healing of wounds
at different phases, such as edema, tissue proliferation, and remodeling. The films contained
marigold, a naturally occurring bioactive component with anti-inflammatory, antioxidant, and
tissue-regeneration qualities. These composite films were made with biopolymers (PLA/kappa
carrageenan) and the crosslinker glutaraldehyde, and they were further enhanced with
marigold. The produced films were characterized using a variety of analytical methods,
including FTIR (Fourier Transform Infrared Spectroscopy), TGA (Thermo gravimetric
analysis), and XRD (X-ray diffraction). Furthermore, a research on edema was carried out.
UV-visible spectroscopy was used to characterize the marigold extract. The morphological
study verified the films' creation and structure. The PLA-kappa carrageenan-marigold
composite films were evaluated for their antibacterial properties against the Escherichia coli
(E. coli) bacterium. As a result, this all-natural composite material has potential as an affordable
base for encouraging good wound healing.
Keywords: Poly lactic acid (PLA), k-carrageenan, marigold, TGA, XRD, FTIR, Antibacterial activity
Publication date: 01/12/2024
https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8567.pdf
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https://doi.org/10.31032/IJBPAS/2024/13.12.8567
