For the purpose of to create biologically active wound dressings, cellulose and kappa
carrageenan were combined in this study using a simple process that involved mixing their
solutions and then connecting them with a glutaraldehyde solution. A range of cellulose to
kappa carrageenan ratios, including 80:20, 60:40, 70:30, and 50:50, were utilized, and the
mechanical, thermal, and swelling characteristics of the resultant films were assessed. These
dressings were developed with a biological purpose in mind, namely for their use in aiding
wound healing at various phases, including swelling, tissue growth, and remodeling. Mehndi,
a naturally occurring bioactive ingredient with anti-inflammatory, antioxidant, and tissue-
regeneration properties, was included into these films. These composite films were made with
the help of mehndi enrichment and biopolymers (cellulose/kappa carrageenan) and the
crosslinker glutaraldehyde. The resulting films were thoroughly examined using a variety of
analytical methods, such as TGA (thermogravimetric analysis), XRD (X-ray diffraction), and
FTIR (Fourier Transform Infrared Spectroscopy). An assessment about edema was also carried
out. The mehndi extract was characterized using UV-visible spectroscopy. The morphological
analysis supported the design and construction of the videos. The antibacterial characteristics
of the cellulose-kappa carrageenan-mehndi composite films were evaluated in relation to the
Escherichia coli (E. coli) bacterium. As a result, this all-natural composite material shows
promise as a cost-effective substrate to encourage efficient wound healing.
Keywords: Cellulose, k-carrageenan, Mehndi (Heena), TGA, XRD, FTIR, Antibacterial activity
Publication date: 01/12/2024
https://ijbpas.com/pdf/2024/December/MS_IJBPAS_2024_8566.pdf
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https://doi.org/10.31032/IJBPAS/2024/13.12.8566
